Four Americans who drove across the U.S.-Mexico border from Texas were fired upon, held at gunpoint and possibly kidnaped, according to the FBI.

Special Agent Oliver Rich, who is in charge of the FBI’s San Antonio Division, announced Sunday that the bureau is seeking public assistance to locate four U.S. citizens who were last seen in the northern Mexico border city of Matamoros, Tamaulipas.

They have been missing since Friday, March 3.

"On March 03, 2023, four Americans crossed into Matamoros, Tamaulipas, Mexico driving a white minivan with North Carolina license plates. Shortly after crossing into Mexico, unidentified gunmen fired upon the passengers in the vehicle. All four Americans were placed in a vehicle and taken from the scene by armed men," the FBI said in a statement.

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Matamoros is located along the U.S.-Mexico border, just across from Brownsville, Texas.

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Investigators from the FBI and its federal partners, as well as Mexican law enforcement agencies, are assisting in the search for the victims.

Matamoros is notorious for warring factions of the Gulf drug cartel, and violence on Friday was so bad that the U.S. Consulate issued an alert.

Tamaulipas state police also said a number of people were killed or suffered injuries that same day but did not provide details on how many were affected.

The FBI has offered a reward of $50,000 for the safe return of the Americans and the arrests of those responsible.

Anyone with information regarding this investigation is encouraged to call FBI San Antonio Division at 210-225-6741.

Tips can also be submitted online at https://tips.fbi.gov. These tips can be submitted anonymously.

The Associated Press contributed to this report