Poster details advances in screening for non-hallucinogenic, neuroplastogen drug candidates for the treatment of mental health disorders
Enveric Biosciences (NASDAQ: ENVB) (“Enveric” or the “Company”), a biotechnology company dedicated to the development of novel neuroplastogenic small-molecule therapeutics for the treatment of depression, anxiety and addiction disorders, today announced a poster presentation highlighting novel screening processes and technologies exclusive to Enveric’s EVM301 Series. The poster will be presented at the International Conference on Molecular Biology and Biochemistry 2023 (ICMBB 2023) taking place in Toronto, Canada from September 18-19. Enveric’s EVM301 Series encompasses new chemical entity (NCE) tryptamine pharmaceutical drug candidates designed to engage the serotonin 5HT2A receptor and other neurotransmitter receptors with the intent to promote neuroplasticity and therapeutic benefit without inducing hallucinatory effects.
During the conference, Jillian Hagel, PhD, VP of Innovation, Enveric Biosciences, will present the poster titled, “Screening for Non-hallucinogenic Neuroplastogens as Drug Candidates for the Treatment of Anxiety, Depression, and Posttraumatic Stress Disorder.” The poster provides an overview of the screening protocol employed in the development of Enveric’s EVM301 Series, which has resulted in the synthesis of a catalog of proprietary compounds derived from the structures of serotonin (5-hydroxytryptamine) and psychedelic molecules such as N,N-dimethyltryptamine (DMT) and psilocin (4-hydroxy-DMT). The poster further highlights protocols for modeling the potential of each compound to reduce or eliminate hallucinations, which may permit the administration of the drug at a dose that induces neuroplasticity and may be beneficial in the targeted treatment of CNS disorders. The poster abstract can be accessed at https://waset.org/conferences-in-september-2023-in-toronto/program.
“We are thrilled to present this compelling and promising research at ICMBB 2023, which elucidates the proprietary techniques and technologies that Enveric is employing in the advancement of our EVM301 Series,” said Dr. Joseph Tucker, President & CEO of Enveric Biosciences. “Our innovative and proprietary artificial intelligence algorithms have enabled our research team to predict the mode of engagement with the 5HT2A receptor, which has facilitated the design and synthesis of novel and high-quality drug molecules. Using a robust series of laboratory assays and animal models to test these candidates, we have generated strong experimental evidence in support of the reduced hallucinogenic effect, neuroplastogenic potential, and promising effects in animal models of depression and anxiety.”
“Our team is committed to developing a next generation of compounds targeting difficult-to-treat mental health disorders. Our EVM301 Series of molecules includes features based on our key insights into the mechanisms of neuroplasticity,” said Dr. Hagel. “I look forward to constructive interactions and discussions with my colleagues at the ICMBB conference, as we represent Enveric in our mission to bring innovative neuroplastogens forward as potential treatments for central nervous system disorders.”
About Enveric Biosciences
Enveric Biosciences (NASDAQ: ENVB) is a biotechnology company dedicated to the development of novel neuroplastogenic small-molecule therapeutics for the treatment of depression, anxiety, and addiction disorders. Leveraging its unique discovery and development platform, The Psybrary™, Enveric has created a robust Intellectual Property portfolio of New Chemical Entities for specific mental health indications. Enveric’s lead program, the EVM201 Series, comprises next generation synthetic prodrugs of the active metabolite, psilocin. Enveric is developing the first product from the EVM201 Series – EB-373 – for the treatment of psychiatric disorders. Enveric is also advancing its second program, the EVM301 Series, expected to offer a first-in-class, new approach to the treatment of difficult-to-address mental health disorders, mediated by the promotion of neuroplasticity without also inducing hallucinations in the patient. Enveric is headquartered in Naples, FL with offices in Cambridge, MA and Calgary, AB Canada. For more information, please visit www.enveric.com.
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