OMB APPROVAL
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                 AMENDMENT NO. 1
                                       TO
                                    FORM T-3


                FOR APPLICATIONS FOR QUALIFICATION OF INDENTURES
                      UNDER THE TRUST INDENTURE ACT OF 1939

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                            Meridian Bioscience, Inc.
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                               (Name of Applicant)

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                             3471 River Hills Drive
                             Cincinnati, Ohio 45244
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                    (Address of principal executive offices)

           SECURITIES TO BE ISSUED UNDER THE INDENTURE TO BE QUALIFIED

------------------------------------------------------- -----------------------
                 Title of Class                                     Amount
------------------------------------------------------- -----------------------
5.0% Convertible Subordinated Debentures due 2013                $16,000,000



Approximate date of proposed public offering:   As soon as practical after the
                                                date of effectiveness of this
                                                Application for Qualification


                     Name and address of agent for service:

                               Mark A. Weiss, Esq.
                       Keating, Muething & Klekamp, P.L.L.
                              1400 Provident Tower
                             One East Fourth Street
                             Cincinnati, Ohio 45202


THE APPLICANT HEREBY AMENDS THIS APPLICATION FOR QUALIFICATION ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVENESS UNTIL (I) THE 20TH DAY
AFTER THE FILING OF AN AMENDMENT THAT SPECIFICALLY STATES THAT IT SHALL
SUPERSEDE THIS APPLICATION FOR QUALIFICATION OR (II) SUCH DATE AS THE SECURITIES
AND EXCHANGE COMMISSION, ACTING PURSUANT TO SECTION 307(C) OF THE TRUST
INDENTURE ACT OF 1939, MAY DETERMINE UPON THE WRITTEN REQUEST OF THE APPLICANT.



                                     GENERAL

1.       GENERAL INFORMATION.

         (a)  Form of organization:  Corporation

         (b)  State or other sovereign power under the laws of which
organized:  Ohio


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2.       SECURITIES ACT EXEMPTION APPLICABLE.


         Upon the terms set forth in an Offering Memorandum dated
November __, 2003, and the related Letter of Transmittal (which together
constitute the "Exchange Offer"), Meridian Bioscience, Inc. (the "Company") is
offering to exchange $16,000,000 in principal amount of the Company's 5.0%
Convertible Subordinated Debentures due 2013 (the "New Debentures") for an equal
principal amount of the Company's 7% Convertible Subordinated Debentures due
2003 (the "Existing Debentures"). The Exchange Offer is being extended to all
holders of the Existing Debentures.


         The Company has engaged D.F. King & Co., Inc. as the Information Agent
for the Exchange Offer to assist in distributing the Offering Memorandum and the
other Exchange Offer materials to the holders of the Existing Debentures. The
Company will pay the Information Agent customary fees for its services and
reimburse the Information Agent for its reasonable out-of-pocket expenses
incurred in connection with the provision of these services.

         The Company has appointed LaSalle Bank, National Association as the
Exchange Agent for the Exchange Offer. The Company will pay the Exchange Agent
customary fees for its services and reimburse the Exchange Agent for its
reasonable out-of-pocket expenses incurred in connection with the provision of
these services. The Company will also pay the Exchange Agent compensation for
services as trustee under the New Debentures indenture and certain of its
expenses related thereto.

         There has not been and there will not be any sales of the New
Debentures by the Company or by or through any underwriter at or about the same
time as the Exchange Offer.

                                  AFFILIATIONS

3.       AFFILIATES.

         See Item 4 for directors and executive officers of the Company, some of
whom may be deemed to be affiliates of the Company by virtue of their position.

         To the Company's knowledge, Item 5 of this Application sets forth the
name and address of the only shareholder of the Company that beneficially owns
10% or more of the Company's voting securities as of September 30, 2003.

         The following list sets forth the relationship among the Company and
all of its principal direct and indirect subsidiaries as of September 30, 2003.
Each of the entities listed below is a wholly-owned subsidiary of the Company.

          1.   Omega Technologies, Inc., an Ohio corporation

          2.   Meridian Bioscience Corporation, an Ohio corporation

          3.   Meridian Bioscience Europe, s.r.l., an Italian corporation

          4.   Meridian Bioscience FSC, Inc., a Barbados corporation

          5.   Gull Laboratories, Inc., a Utah corporation

          6.   BIODESIGN International Incorporated, a Maine corporation

          7.   Meridian Bioscience Europe S.A., a Belgium corporation

          8.   Gull Europe S.A. Holding, a Belgium corporation


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          9.   Meridian Bioscience Europe B.V., a Netherlands corporation

          10.  Viral Antigens, Inc., a Tennessee corporation

                             MANAGEMENT AND CONTROL

4.       DIRECTORS AND EXECUTIVE OFFICERS.

         The following table sets forth the name and office of all directors and
executive officers of the Company as of September 30, 2003. The address of each
director and executive officer is c/o Meridian Bioscience, Inc., 3471 River
Hills Drive, Cincinnati, Ohio 45244.



                          
---------------------------- ---------------------------------------------------------------
       Name                                      Position
---------------------------- ---------------------------------------------------------------
William J. Motto             Chairman of the Board of Directors, Chief Executive Officer
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
John A. Kraeutler            President, Chief Operating Officer and Director
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Antonio A. Interno           Senior Vice President
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Richard L. Eberly            Executive Vice President
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Kenneth J. Kozak             Vice President, Research and Development
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Melissa A. Lueke             Vice President, Chief Financial Officer and Secretary
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Susan A. Rolih               Vice President of Regulatory Affairs & Quality Systems
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Lawrence J. Baldini          Vice President of Operations
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
James A. Buzard, Ph.D.       Director
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Gary P. Kreider              Director
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
Robert J. Ready              Director
---------------------------- ---------------------------------------------------------------
---------------------------- ---------------------------------------------------------------
David C. Phillips            Director
---------------------------- ---------------------------------------------------------------



5.       PRINCIPAL OWNERS OF VOTING SECURITIES.

         The following table sets forth, as of September 30, 2003, the security
ownership of each person who was known by the Company to beneficially own 10% or
more of the voting securities of the Company.



---------------------------------- ------------------------- ---------------------------- ----------------------------
        Name and Complete                  Title of                 Amount Owned             Percentage of Voting
         Mailing Address                 Class Owned                                           Securities Owned
---------------------------------- ------------------------- ---------------------------- ----------------------------
                                                                                  

William J. Motto                         Common Stock                 4,002,146                      27.1%
c/o Meridian Bioscience, Inc.
3471 River Hills Drive
Cincinnati, Ohio  45244

                                  UNDERWRITERS

6.       UNDERWRITERS.

         (a)  Persons acting as underwriters within the last three years: None

         (b)  The New Debentures will not be offered or sold by or through any
underwriter.

                               CAPITAL SECURITIES

7.       CAPITALIZATION.

         (a) The following table sets forth, as of September 30, 2003, certain
information as to each authorized class of securities of the Company:

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------------------------------------------------------- ------------------------ -------------------------------------
                    Title of Class                         Amount Authorized            Amount Outstanding(2)
------------------------------------------------------- ------------------------ -------------------------------------
                                                                                     
Common Stock, without par value(1)                            50,000,000                      14,728,590
7% Convertible Subordinated Debentures due 2006               $20,000,000                    $20,000,000


(1)      The holders of Common Stock are entitled to one vote per share on all
         matters to be voted upon by the shareholders, and are entitled to
         cumulate their votes in the election of directors.
(2)      Convertible into Common Stock at $16.09 per share.

                              INDENTURE SECURITIES

8. ANALYSIS OF INDENTURE PROVISIONS. The New Debentures will be issued under the
terms of an indenture to be entered into between the Company and LaSalle Bank,
National Association, as trustee (the "Indenture"). The following is an analysis
of the Indenture provisions required under Section 305(a)(2) of the Trust
Indenture Act of 1939, as amended.

         EVENTS OF DEFAULT.

An event of default as provided in the Indenture includes:

     -    default in the payment of any installment of interest upon any of the
          New Debentures as and when the same shall become due and payable, and
          continuance of such default for a period of 15 days;

     -    default in payment of principal or premium, if any, on the New
          Debentures when the same becomes due and payable at maturity, upon
          redemption or otherwise, whether or not prohibited by the
          subordination provisions of the Indenture;

     -    default for 30 days after notice in the observance or performance of
          any other covenant in the Indenture;

     -    default under any obligations for money borrowed of $1,000,000 or
          more; or

     -    certain events involving our bankruptcy, insolvency, or
          reorganization.

The Indenture provides that the trustee is required, within 90 days after the
occurrence of a default which is known to the trustee and is continuing, to give
to the holders of the New Debentures notice of such default. The trustee is,
however, except in the case of default in the payment of principal or premium,
if any, or interest on any of the New Debentures, in withholding such notice if
it in good faith determines that the withholding of such notice is in the
interest of the holders of the New Debentures.

The Indenture provides that if any event of default has occurred and is
continuing, the trustee or the holders of not less than 25% in principal amount
of the New Debentures then outstanding may declare the principal of all the New
Debentures to be due and payable immediately, but if we cure all defaults (other
than the nonpayment of interest and premium, if any, on and principal of any New
Debentures which shall have become due solely by reason of acceleration) and
certain other conditions are met, such declaration may be annulled and past
defaults may be waived by the holders of a majority in principal amount of the
New Debentures then outstanding.

The holders of a majority in principal amount of the New Debentures then
outstanding will have the right to direct the time, method and place of
conducting any proceeding for any remedy available to the trustee subject to
certain limitations specified in the Indenture.

In certain cases, the holders of a majority in principal amount of the
outstanding New Debentures may on behalf of the holders of all New Debentures
waive any past default or event of default except, unless cured, a default in
the payment of the principal of, premium, if any, or interest on any of the New
Debentures (other than the nonpayment interest and premium, if any, on and
principal of any New Debentures which shall become due by acceleration) or a

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default relating to an obligation of ours which cannot be modified without the
consent of the holder of each New Debenture affected.

         AUTHENTICATION AND DELIVERY AND APPLICATION OF PROCEEDS.

The New Debentures shall be executed on behalf of the Company by its President
or Vice President and attested by its Secretary or one of its Assistant
Secretaries. The signature of any of these officers on the Debentures may be
manual or facsimile.

New Debentures bearing the manual or facsimile signatures of individuals who
were at any time the proper officers of the Company shall bind the Company,
notwithstanding that such individuals or any of them have ceased to hold such
offices prior to the authentication and delivery of such New Debentures or did
not hold such offices at the date of such New Debentures.

Upon the original issuance of the New Debentures by the Company and
authentication by the Trustee, the Trustee shall deliver the Debentures to the
Holders.

All New Debentures authenticated for original issuance by the Company to the
initial purchaser thereof shall be dated as of their respective Date of Issue.
All New Debentures authenticated for any other purpose hereunder shall be dated
the date of their authentication.

No New Debenture shall be entitled to any benefit under this Indenture or be
valid or obligatory for any purpose, unless there appears on such New Debenture
a certificate of authentication substantially in the form provided for herein
executed by the Trustee by manual signature, and such certificate upon any New
Debenture shall be conclusive evidence, and the only evidence, that such New
Debenture has been duly authenticated and delivered hereunder.

The Company will receive no proceeds from the issuance of the New Debentures.

         SATISFACTION AND DISCHARGE OF INDENTURE

The Indenture shall cease to be of further effect (except as to any surviving
rights of conversion, transfer or exchange of New Debentures expressly provided
for), and the Trustee, on demand of and at the expense of the Company, shall
execute the proper instrument acknowledging satisfaction and discharge of this
Indenture, when

     (a) either

               1. all New Debentures theretofore authenticated and delivered,
          other than New Debentures which have been destroyed, lost or stolen
          and which have been replaced or paid as provided in the Indenture,
          have been canceled by the Trustee or delivered for cancellation to the
          Trustee; or

               2. all such New Debentures not theretofore canceled or delivered
          to the Trustee for cancellation have become due and payable, or will
          become due and payable at their Stated Maturity within one year, or
          are to be called for redemption within one year under arrangements
          satisfactory to the Trustee for the giving of notice of redemption by
          the Trustee in the name, and at the expense, of the Company

and the Company, in the case of paragraph (2) above, has deposited or caused to
be deposited with the Trustee as trust funds in trust for the purpose an amount
sufficient to pay and discharge the entire indebtedness on such New Debentures
not theretofore canceled or delivered to the Trustee for cancellation, for
principal and any premium and interest to the date of such deposit, in the case
of Debentures which have become due and payable, or to the stated maturity or
redemption date, as the case may be;

     (b) the Company has paid or caused to be paid all other sums payable
hereunder by the Company; and

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     (c) the Company has delivered to the Trustee an Officers' Certificate and
an Opinion of Counsel, each stating that all conditions precedent herein
provided for relating to the satisfaction and discharge of the Indenture have
been complied with.

Notwithstanding the satisfaction and discharge of this Indenture, the
obligations of the Company to the Trustee under specified sections of the
Indenture shall survive.

         EVIDENCE OF COMPLIANCE

Upon any application or request by the Company to the Trustee to take any action
under any provision of this Indenture, the Company shall furnish to the Trustee
an Officers' Certificate stating that all conditions precedent, if any, provided
for in this Indenture relating to the proposed action have been complied with
and, if requested by the Trustee, an Opinion of Counsel stating that in the
opinion of such Counsel all such conditions precedent, if any, have been
complied with, except that in the case of any such application or request as to
which the furnishing of such documents is specifically required by any provision
of this Indenture relating to such particular application or request, no
additional certificate or opinion need be furnished.

Every Officers' Certificate or Opinion of Counsel with respect to compliance
with a condition or covenant provided for in this Indenture (other than
certificates provided pursuant to Section 314(a)(4) of the Trust Indenture Act)
shall include:

     (a) a statement that each individual signing such Officers' Certificate or
Opinion of Counsel has read such covenant or condition and the definitions
herein relating thereto;

     (b) a brief statement as to the nature and scope of the examination or
investigation upon which the statements or opinions contained in such Officers'
Certificate or Opinion of Counsel are based;

     (c) a statement that, in the opinion of each such individual, he or she has
made such examination or investigation as is necessary to enable him or her to
express an informed opinion as to whether or not such covenant or condition has
been complied with; and

     (d) a statement as to whether, in the opinion of each such individual, such
condition or covenant has been complied with.

9.   OTHER OBLIGORS.

     None.

     CONTENTS OF APPLICATION FOR QUALIFICATION. This application for
qualification comprises -

     (a) Pages numbered 1 to 7 consecutively.

     (b) The statement of eligibility and qualification of each trustee under
the indenture to be qualified.

     (c) The following exhibits in addition to those filed as a part of the
statement of eligibility and qualification of each trustee.

Exhibit T3A       Articles of Incorporation of the Registrant (incorporated
                  by reference to Exhibit 3.1 of the Registration Statement on
                  Form S-3 (File No. 333-02613) filed by the Registrant on April
                  18, 1996).

Exhibit T3B       Code of Regulations of the Registrant (incorporated by
                  reference to Exhibit 3.2 of the Registration Statement on Form
                  S-1 (File No. 33-6052) filed by the Registrant on May 29,
                  1986).

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Exhibit T3C       Form of Indenture relating to the 5% Convertible
                  Subordinated Debentures due 2013, to be entered into by and
                  between Meridian Bioscience, Inc. and LaSalle Bank, National
                  Association, as Trustee (incorporated by reference to Exhibit
                  (d)(2) of Meridian Bioscience, Inc.'s Schedule TO filed
                  October 24, 2003).

Exhibit T3D       Not applicable.

Exhibit T3E 1.    Offering Memorandum, dated October __, 2003
                  (incorporated by reference to Exhibit (a)(1) of Schedule TO
                  filed October 24, 2003).

Exhibit T3E 2.    Form of Letter of Transmittal (incorporated by
                  reference to Exhibit (a)(2) of Schedule TO filed October 24,
                  2003).

Exhibit T3E 3.    Form of Notice of Guaranteed Delivery (incorporated by
                  reference to Exhibit (a)(3) of Schedule TO filed October 24,
                  2003).

Exhibit T3E 4.    Form of Letter to Clients (incorporated by reference to
                  Exhibit (a)(4) of Schedule TO filed October 24, 2003).

Exhibit T3E 5.    Form of Letter to Brokers, Dealers, Commercial Banks,
                  Trust Companies and Other Nominees (incorporated by reference
                  to Exhibit (a)(5) of Schedule TO filed October __, 2003).

*Exhibit T3E 7.   Press Release, dated _____________ .

Exhibit T3F       Cross reference sheet showing the location in the
                  Indenture of the provisions inserted therein pursuant to
                  Sections 310 through 318(a), inclusive, of the Trust Indenture
                  Act of 1939, as amended (included in Exhibit T3C hereto).

* to be filed by amendment

                                    SIGNATURE


         Pursuant to the requirements of the Trust Indenture Act of 1939, the
applicant, Meridian Bioscience, Inc., a corporation organized and existing under
the laws of Ohio, has duly caused this application to be signed on its behalf by
the undersigned, thereunto duly authorized, all in the city of Cincinnati, and
State of Ohio, on the 6th day of November, 2003.


                                        MERIDIAN BIOSCIENCE, INC.


                                        By:  /s/ John A. Kraeutler
                                           ----------------------------
                                                 John A. Kraeutler
                                                 President
Attest:    /s/ Melissa A. Lueke
         ----------------------
         Melissa A. Lueke
         Secretary



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