UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  FORM 8-K/A-1

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                               September 20, 2006

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
               (state or other juris- (Commission (I.R.S. Employer
           diction of incorporation) File Number) (Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080


          (Former name or former address, if changed since last report)


     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
           following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))






Section 4 - Matters Related to Accountants and Financial Statements


Item 4.01 Changes in The Registrant's Certifying Accountant.


         The  Registrant's  Board  of  Directors,   with  the  approval  of  the
Registrant's  audit  committee,  on August 23, 2006 authorized the Registrant to
invite  proposals from a select number of independent  accounting  firms for the
purpose of becoming the Registrant's independent accounting firm.

         BDO Seidman,  LLP ("BDO") informed the Registrant on September 18, 2006
that it will resign from the client-auditor  relationship with the Registrant no
later than the date of the  Registrant's  filing of its Form 10-Q report for the
period ending  September 30, 2006.  BDO's decision to resign was not recommended
or approved by the Registrant's Audit Committee.

         BDO's reports on financial  statements of the Registrant for the fiscal
years ended  December 31, 2004 and December 31, 2005 did not contain any adverse
opinion or any  disclaimer  of opinion and were not  qualified or modified as to
uncertainty, audit scope or accounting principles.

         During the fiscal years ended  December 31, 2004 and December 31, 2005,
and the  subsequent  interim period  preceding the date of this amended  Current
Report on Form 8-K, there were no  disagreements  between the Registrant and BDO
on  any  matter  of  accounting  principals  or  practice,  financial  statement
disclosure  or  auditing  scope  of  procedure  which,  if not  resolved  to the
satisfaction  of BDO,  would have caused BDO to make a reference  to the subject
matter thereof in connection with its reports and, during the same period, there
were no  reportable  events as defined in item  304(a)(1)(v)  of the  Commission
Regulation  S-K,  except as previously  reported in Item 9A of the  Registrant's
2005 Form 10-K/A2.

         Promptly  after BDO  resigns,  the  Registrant  will amend this Current
Report on Form 8-K to disclose the resignation and update the other  information
contained herein.

Section 9 - Financial Statements and Exhibits Item 9.01 Financial Statements and
Exhibits.

(c)      Exhibits


Exhibit No.                Description

16                         Letter on change in certifying accountant.







                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                   HEMISPHERX BIOPHARMA, INC.



September 22, 2006               By: /S/ Robert peterson
                                   ----------------------------------------
                                   Robert Peterson, Chief Financial Officer