UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                     February 14, 2005 ( February 18, 2005)

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
               (state or other juris- (Commission (I.R.S. Employer
           diction of incorporation) File Number) (Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080

                                                                       
          (Former name or former address, if changed since last report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12) [ ] Pre-commencement  communications pursuant to Rule 14d-2(b) under
the Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))








Section 1 - Registrant's Business and Operations

Item 1.01 Entry into a Material Definitive Agreement.

See Item 5.02 below.

Section 5 - Corporate Governance and Management
-----------------------------------------------
 
Item 5.02 Departure of Directors or Principal  Officers;  Election of Directors;
Appointment of Principal Officers.

On February 14, 2005, we entered into an agreement with The Sage Group, Inc., an
international  organization providing senior level strategic management services
to the  biotechnology  and  pharmaceutical  sector, to retain the services of R.
Douglas  Hulse as our  President and Chief  Operating  Officer.  Mr. Hulse is an
executive director of The Sage Group, Inc.

Mr. Hulse,  a Phi Beta Kappa graduate of Princeton  University  with a cum laude
degree in  chemistry  and the  holder of S.M.  Degrees  in both  management  and
Chemical  Engineering from M.I.T.,  is an executive  director of The Sage Group,
Inc.  He  previously  served as our Chief  Operating  Officer  in 1996 and 1997.
During his earlier tenure with us, Mr. Hulse was instrumental in the development
of the liquid form of the  experimental  immunotherapeutic,  Ampligen(R),  and a
plan  for  scaled  up  manufacturing  production  to meet  potential  commercial
requirements.  Mr.  Hulse  has  planned,  negotiated,  and  implemented  various
strategic alliances with North American,  European and Asian partners during his
career.

Mr. Hulse will devote approximately two to two and one half days per week to our
business.  His  specific  activities  in his  new  positions  will  be  mutually
determined  by him and our  Chairman.  We anticipate  that the  engagement  will
continue for a period of 18 months; however, it is terminable on 30 days written
notice by either party.

For Mr.  Hulse's  services,  The Sage Group will  receive a monthly  retainer of
$10,000 and a 10 year warrant to purchase  250,000 shares of our common stock at
an exercise  price equal to the closing price of our stock on February 14, 2005.
The warrant  will vest at the rate of 12,500 share per month with a final 25,000
shares  vesting upon  completion  of the 18th month of the  engagement.  Vesting
accelerates  in the event of a merger or a purchase  of a majority of our assets
or equity.  In addition,  For each calendar year (or part thereof)  during which
the  agreement is in effect,  Sage will be entitled to an incentive  bonus in an
amount equal to 0.5% of the gross proceeds  received by us during such year from
any joint ventures or corporate  partnering  arrangements.  After termination of
the agreement,  Sage will only be entitled to receive the incentive  bonus based
upon gross proceeds  received by us during the two year period commencing on the
termination  of the  agreement  with respect to any joint  ventures or corporate
partnering arrangements entered into by us during the term of the agreement. Mr.
Hulse is  entitled to  insurance  commensurate  with that  provided to our other
officers.

Dr. William Carter resigned as our President effective upon the execution of the
Sage agreement.  Dr. Carter remains our Chief Executive  Officer and Chairman of
our Board of Directors.

                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            HEMISPHERX BIOPHARMA, INC.


February 17, 2005                       By: /s/ William A. Carter
                                            ---------------------
                                            William A. Carter M.D.,
                                            Chief Executive Officer