The markets welcomed French centrist candidate Emmanuel Macron's first round victory in the presidential elections this weekend. The markets closed sharply higher with the Dow surging 216 points to 20,763. Nasdaq leaped 73 points to 5,983.

On the upside

The European Medicines Agency granted orphan drug designation to PhaseRX (Nasdaq: PZRX) for its PRX-OTC to treat ornithine transcarbyamylase deficiency.

Deutsche Bank (NYSE: DB) hired two senior Healthcare Investment Bankers from BMO Capital Markets.

Shares of Rocket Fuel (Nasdaq: FUEL) surged on no news.

On the downside

ContraVir Pharmaceuticals (Nasdaq: CTRV) announced a proposed public offering of common stock and warrants.

Immune Pharmaceuticals (Nasdaq: IMNP) named Dr. Daniel Teper to lead the oncology business of its Cytovia subsidiary and to pursue a potential spin-off of Cytovia.

Investors locked in profits on Globus Maritime (Nasdaq: GLBS).

In the broad market, advancing issues outpaced decliners by a margin of nearly 5 to 2 on both the NYSE and on Nasdaq. The broader S&P 500 index jumped 25 points to 2,374. Bitcoin gained $9 to $1249.