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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                        --------------------------------

                                    FORM 8-K
                        --------------------------------


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): DECEMBER 13, 2004

                             -----------------------

                                 CRYOLIFE, INC.
             (Exact name of registrant as specified in its charter)
                            -------------------------



                                                                   
                FLORIDA                           1-13165                    59-2417093
     (State or Other Jurisdiction        (Commission File Number)           (IRS Employer
           of Incorporation)                                             Identification No.)


              1655 ROBERTS BOULEVARD, N.W., KENNESAW, GEORGIA 30144
               (Address of principal executive office) (zip code)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (770) 419-3355

          -------------------------------------------------------------
          (Former name or former address, if changed since last report)

                            -------------------------

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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SECTION 1         REGISTRANT'S BUSINESS AND OPERATIONS.
ITEM 1.02.        TERMINATION OF A MATERIAL DEFINITIVE CONTRACT.

See Item 8.01 below,  regarding  the  termination  of  employment  of two former
officers of CryoLife, Inc. (the "Company" or "CryoLife"), which may be deemed to
be material.


SECTION 8         OTHER EVENTS.
ITEM 8.01.        OTHER EVENTS.

On  January  10,  2005,  CryoLife  issued  a  press  release  relating  to a new
development  and  marketing  agreement  with  Endologix,  Inc.  CryoLife  hereby
incorporates by reference  herein the information set forth in its Press Release
dated January 10, 2005, a copy of which is attached hereto as Exhibit 99.1.

As  previously  announced,  on December  13, 2004,  Dr. Kirby Black  resigned as
CryoLife's  Senior Vice  President  of  Research  and  Development.  His written
employment agreement had previously expired according to its terms. He continued
employment with CryoLife under an at-will arrangement at an annualized salary of
$253,000 until December 13, 2004.

On December 14, 2004, Albert E. Heacox, PhD, assumed the position of Senior Vice
President  of  Research  and   Development   with  CryoLife.   CryoLife   hereby
incorporates by reference  herein the information set forth in its press release
dated December 14, 2004, a copy of which is attached as Exhibit 99.2.

On December 14, 2004,  Dr. James C. Vander Wyk's  employment as Vice  President,
Product  Integrity  with  CryoLife  terminated.  Dr.  Vander Wyk worked under an
employment  agreement  entered  into in  September  2002 at an annual  salary of
$240,000.  Upon his  departure,  CryoLife  agreed  to pay the  severance  amount
provided for in his employment  agreement of eighteen months of base salary. For
more than six months prior to his departure,  Dr. Vander Wyk was not in a policy
making position at the Company.  His primary  responsibilities  during that time
were to assist the Company in defending against several lawsuits.

This  Form 8-K also is filed to  include  a copy of the Form of  Indemnification
Agreement, previously reported, for the Directors and Chief Financial Officer of
the Company.

CryoLife has entered into indemnification  agreements with each of its directors
and its Chief Financial  Officer  ("Indemnitees").  Pursuant to such agreements,
CryoLife shall indemnify each Indemnitee whenever he or she is or was a party or
is threatened to be made a party to any proceeding, including without limitation
any such proceeding brought by or in the right of CryoLife, because he or she is
or was a director or officers of CryoLife or is or was serving at the request of
CryoLife as a director  or officer of another  corporation,  partnership,  joint
venture,  trust or other enterprise,  or because of anything done or not done by
the Indemnitee in such capacity, against expenses and liabilities (including the
costs  of  any  investigation,  defense,  settlement  or  appeal)  actually  and
reasonably incurred by the Indemnitee or on his or her behalf in connection with
such  proceeding,  if he or she  acted in good  faith  and in a manner he or she
reasonably  believed to be in or not opposed to the best  interests of CryoLife,
and, with respect to any criminal action or proceeding,  had no reasonable cause
to believe his or her conduct was unlawful.  The  termination of any action suit


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or proceeding by judgment, order, settlement, conviction, or upon a plea of nolo
contendere or its equivalent, shall not, of itself, create a presumption that an
Indemnitee  did not act in good faith and in a manner which he or she reasonably
believed to be in or not opposed to the best  interests of CryoLife,  and,  with
respect to any criminal  action or proceeding,  had reasonable  cause to believe
that his or her conduct was unlawful.  Unless a determination has been made that
the Indemnitee is not entitled to indemnification pursuant to the agreement, all
reasonable  expenses  incurred  by or on  behalf  of such  Indemnitee  shall  be
advanced from time to time by CryoLife to the Indemnitee within thirty (30) days
after CryoLife's receipt of a written request for an advance of expenses by such
Indemnitee,  whether prior to or after final  disposition  of a  proceeding.  If
required by law,  Indemnitee shall agree, at the time of such advance,  to repay
the amounts  advanced if it is  ultimately  determined  that  Indemnitee  is not
entitled to be indemnified  under the terms of the agreement.  Any advances made
shall be unsecured and no interest shall be charged thereon.

The indemnification  agreements were executed by the Company and each Indemnitee
on the date indicated on Exhibit 10.50.

Insofar as indemnification  for liabilities  arising under the Securities Act of
1933 (the "1933  Act"),  may be  permitted  to  directors,  officers  or persons
controlling  CryoLife  pursuant  to the  foregoing  provisions  of  the  Georgia
Business  Corporation Code and CryoLife's  articles of incorporation and bylaws,
CryoLife has been informed that  indemnification is considered by the Commission
to be against public policy and therefore unenforceable.

ITEM 9.01(C)  EXHIBITS.

    Exhibit Number    Description
    --------------    -----------

    10.50             Form of Indemnification Agreement for Directors and
                      Chief Financial Officer of the Registrant (incorporated by
                      reference to Exhibit 99.1 to the Registrant's Registration
                      Statement  on Form S-3  (File No. 333-121406)).

    99.1              Press Release dated January 10, 2005

    99.2              Press Release dated December 14, 2004





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                                   SIGNATURES

     Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,
CryoLife,  Inc.  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                       CRYOLIFE, INC.



Date:  January 12, 2005                By:  /s/ D. Ashley Lee
                                           -------------------------------------
                                           Name:    D. Ashley Lee
                                           Title:   Executive  Vice  President, 
                                           Chief  Operating  Officer and Chief
                                           Financial Officer



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                                  EXHIBIT INDEX


    Exhibit Number    Description
    --------------    -----------

    10.50             Form of Indemnification Agreement for Directors and
                      Chief Financial Officer of the Registrant (incorporated by
                      reference to Exhibit 99.1 to the Registrant's Registration
                      Statement  on Form S-3  (File No. 333-121406)).

    99.1              Press Release dated January 10, 2005

    99.2              Press Release dated December 14, 2004





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