*
|
The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
|
CUSIP No. 75901B107
|
Page 2 of 18
|
1.
|
Name of Reporting Persons
Venrock Healthcare Capital Partners, L.P.
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
1,083,4542
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
1,083,4542
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
1,083,4542
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
4.1%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
PN
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 44,381 shares owned by VHCP I, 8,119 shares owned by VHCP Co-Invest I, 783,474 shares owned by VHCP II and 247,480 shares owned by VHCP Co-Invest II.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 908,453 shares of common stock held by VA7 and VP7. The VHCP Entities disclaim beneficial ownership over the shares held by the Venrock 7 Entities.
|
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 3 of 18
|
1.
|
Name of Reporting Persons
VHCP Co-Investment Holdings, LLC
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
1,083,4542
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
1,083,4542
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
1,083,4542
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
4.1%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
OO
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 44,381 shares owned by VHCP I, 8,119 shares owned by VHCP Co-Invest I, 783,474 shares owned by VHCP II and 247,480 shares owned by VHCP Co-Invest II.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 908,453 shares of common stock held by VA7 and VP7. The VHCP Entities disclaim beneficial ownership over the shares held by the Venrock 7 Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 4 of 18
|
1.
|
Name of Reporting Persons
Venrock Healthcare Capital Partners II, L.P.
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
1,083,4542
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
1,083,4542
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
1,083,4542
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
4.1%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
PN
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 44,381 shares owned by VHCP I, 8,119 shares owned by VHCP Co-Invest I, 783,474 shares owned by VHCP II and 247,480 shares owned by VHCP Co-Invest II.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 908,453 shares of common stock held by VA7 and VP7. The VHCP Entities disclaim beneficial ownership over the shares held by the Venrock 7 Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 5 of 18
|
1.
|
Name of Reporting Persons
VHCP Co-Investment Holdings II, LLC
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
1,083,4542
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
1,083,4542
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
1,083,4542
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
4.1%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
OO
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 44,381 shares owned by VHCP I, 8,119 shares owned by VHCP Co-Invest I, 783,474 shares owned by VHCP II and 247,480 shares owned by VHCP Co-Invest II.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 908,453 shares of common stock held by VA7 and VP7. The VHCP Entities disclaim beneficial ownership over the shares held by the Venrock 7 Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 6 of 18
|
1.
|
Name of Reporting Persons
VHCP Management, LLC
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
1,083,4542
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
1,083,4542
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
1,083,4542
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
4.1%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
OO
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 44,381 shares owned by VHCP I, 8,119 shares owned by VHCP Co-Invest I, 783,474 shares owned by VHCP II and 247,480 shares owned by VHCP Co-Invest II.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 908,453 shares of common stock held by VA7 and VP7. The VHCP Entities disclaim beneficial ownership over the shares held by the Venrock 7 Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 7 of 18
|
1.
|
Name of Reporting Persons
VHCP Management II, LLC
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
1,083,4542
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
1,083,4542
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
1,083,4542
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
4.1%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
OO
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 44,381 shares owned by VHCP I, 8,119 shares owned by VHCP Co-Invest I, 783,474 shares owned by VHCP II and 247,480 shares owned by VHCP Co-Invest II.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 908,453 shares of common stock held by VA7 and VP7. The VHCP Entities disclaim beneficial ownership over the shares held by the Venrock 7 Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 8 of 18
|
1.
|
Name of Reporting Persons
Venrock Associates VII, L.P.
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
908,4532
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
908,4532
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
908,4532
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
3.5%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
PN
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 838,956 shares owned by VA7 and 69,497 shares owned by VP7.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 1,083,454 shares of common stock held by VHCP I, VHCP Co-Invest I, VHCP II and VHCP Co-Invest II. The Venrock 7 Entities disclaim beneficial ownership over the shares held by the VHCP Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 9 of 18
|
1.
|
Name of Reporting Persons
Venrock Partners VII, L.P.
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
908,4532
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
908,4532
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
908,4532
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
3.5%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
PN
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 838,956 shares owned by VA7 and 69,497 shares owned by VP7.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 1,083,454 shares of common stock held by VHCP I, VHCP Co-Invest I, VHCP II and VHCP Co-Invest II. The Venrock 7 Entities disclaim beneficial ownership over the shares held by the VHCP Entities.
|
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 10 of 18
|
1.
|
Name of Reporting Persons
Venrock Management VII, LLC
|
|||||
2.
|
Check the Appropriate Box if a Member of a Group (See Instructions)
(a) ¨ (b) x1
|
|||||
3.
|
SEC USE ONLY
|
|||||
4.
|
Citizenship or Place of Organization
Delaware
|
|||||
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With:
|
|
5.
|
|
Sole Voting Power
0
|
||
|
6.
|
|
Shared Voting Power
908,4532
|
|||
|
7.
|
|
Sole Dispositive Power
0
|
|||
|
8.
|
|
Shared Dispositive Power
908,4532
|
|||
9.
|
Aggregate Amount Beneficially Owned by Each Reporting Person
908,4532
|
|||||
10.
|
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x3
|
|||||
11.
|
Percent of Class Represented by Amount in Row (9)
3.5%4
|
|||||
12.
|
Type of Reporting Person (See Instructions)
OO
|
1
|
This Schedule 13G is being filed by Venrock Healthcare Capital Partners, L.P. (“VHCP I”), VHCP Co-Investment Holdings, LLC (“VHCP Co-Invest I”), Venrock Healthcare Capital Partners II, L.P. (“VHCP II”), VHCP Co-Investment Holdings II, LLC (“VHCP Co-Invest II”), VHCP Management, LLC (“VHCP Management”), VHCP Management II, LLC (“VHCP Management II” and collectively with VHCP I, VHCP Co-Invest I, VHCP II, VHCP Co-Invest II and VHCP Management, the “VHCP Entities”), Venrock Associates VII, L.P. (“VA7”), Venrock Partners VII, L.P. (“VP7”) and Venrock Management VII, LLC (“VM7” and together with VA7 and VP7, the “Venrock 7 Entities” and the Venrock 7 Entities together with the VHCP Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.
|
2
|
Consists of 838,956 shares owned by VA7 and 69,497 shares owned by VP7.
|
3
|
The shares included on rows 6, 8 and 9 do not include an aggregate of 1,083,454 shares of common stock held by VHCP I, VHCP Co-Invest I, VHCP II and VHCP Co-Invest II. The Venrock 7 Entities disclaim beneficial ownership over the shares held by the VHCP Entities.
|
||
4
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
CUSIP No. 75901B107
|
Page 11 of 18
|
Item 1.
|
(a)
|
Name of Issuer
|
(b)
|
Address of Issuer’s Principal Executive Offices
|
Item 2.
|
(a)
|
Name of Person Filing
|
(b)
|
Address of Principal Business Office or, if none, Residence
|
New York Office:
|
|
Palo Alto Office:
|
|
Boston Office:
|
530 Fifth Avenue
|
|
3340 Hillview Avenue
|
|
470 Atlantic Avenue
|
22nd Floor
|
|
Palo Alto, CA 94304
|
|
4th Floor
|
New York, NY 10036
|
|
|
Boston, MA 02210
|
CUSIP No. 75901B107
|
Page 12 of 18
|
(c)
|
Citizenship
|
(d)
|
Title of Class of Securities
|
(e)
|
CUSIP Number
|
Item 3.
|
If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:
|
Item 4.
|
Ownership
|
Venrock Healthcare Capital Partners, L.P.
|
1,083,454 (1)
|
VHCP Co-Investment Holdings, LLC
|
1,083,454 (1)
|
Venrock Healthcare Capital Partners II, L.P.
|
1,083,454 (1)
|
VHCP Co-Investment Holdings II, LLC
|
1,083,454 (1)
|
VHCP Management, LLC
|
1,083,454 (1)
|
VHCP Management II, LLC
|
1,083,454 (1)
|
Venrock Associates VII, L.P.
|
908,453 (2)
|
Venrock Partners VII, L.P.
|
908,453 (2)
|
Venrock Management VII, LLC
|
908,453 (2)
|
Venrock Healthcare Capital Partners, L.P.
|
4.1% (3)
|
VHCP Co-Investment Holdings, LLC
|
4.1% (3)
|
Venrock Healthcare Capital Partners II, L.P.
|
4.1% (3)
|
VHCP Co-Investment Holdings II, LLC
|
4.1% (3)
|
VHCP Management, LLC
|
4.1% (3)
|
VHCP Management II, LLC
|
4.1% (3)
|
Venrock Associates VII, L.P.
|
3.5% (3)
|
Venrock Partners VII, L.P.
|
3.5% (3)
|
Venrock Management VII, LLC
|
3.5% (3)
|
(c)
|
Number of shares as to which the person has, as of December 31, 2015:
|
CUSIP No. 75901B107
|
Page 13 of 18
|
Venrock Healthcare Capital Partners, L.P.
|
0
|
VHCP Co-Investment Holdings, LLC
|
0
|
Venrock Healthcare Capital Partners II, L.P.
|
0
|
VHCP Co-Investment Holdings II, LLC
|
0
|
VHCP Management, LLC
|
0
|
VHCP Management II, LLC
|
0
|
Venrock Associates VII, L.P.
|
0
|
Venrock Partners VII, L.P.
|
0
|
Venrock Management VII, LLC
|
0
|
Venrock Healthcare Capital Partners, L.P.
|
1,083,454 (1)
|
VHCP Co-Investment Holdings, LLC
|
1,083,454 (1)
|
Venrock Healthcare Capital Partners II, L.P.
|
1,083,454 (1)
|
VHCP Co-Investment Holdings II, LLC
|
1,083,454 (1)
|
VHCP Management, LLC
|
1,083,454 (1)
|
VHCP Management II, LLC
|
1,083,454 (1)
|
Venrock Associates VII, L.P.
|
908,453 (2)
|
Venrock Partners VII, L.P.
|
908,453 (2)
|
Venrock Management VII, LLC
|
908,453 (2)
|
Venrock Healthcare Capital Partners, L.P.
|
0
|
VHCP Co-Investment Holdings, LLC
|
0
|
Venrock Healthcare Capital Partners II, L.P.
|
0
|
VHCP Co-Investment Holdings II, LLC
|
0
|
VHCP Management, LLC
|
0
|
VHCP Management II, LLC
|
0
|
Venrock Associates VII, L.P.
|
0
|
Venrock Partners VII, L.P.
|
0
|
Venrock Management VII, LLC
|
0
|
Venrock Healthcare Capital Partners, L.P.
|
1,083,454 (1)
|
VHCP Co-Investment Holdings, LLC
|
1,083,454 (1)
|
Venrock Healthcare Capital Partners II, L.P.
|
1,083,454 (1)
|
VHCP Co-Investment Holdings II, LLC
|
1,083,454 (1)
|
VHCP Management, LLC
|
1,083,454 (1)
|
VHCP Management II, LLC
|
1,083,454 (1)
|
Venrock Associates VII, L.P.
|
908,453 (2)
|
Venrock Partners VII, L.P.
|
908,453 (2)
|
Venrock Management VII, LLC
|
908,453 (2)
|
CUSIP No. 75901B107
|
Page 14 of 18
|
(1)
|
These shares are owned directly as follows: 44,381 shares are owned by VHCP I, 8,119 shares are owned by VHCP Co-Invest I, 783,474 shares are owned by VHCP II and 247,480 shares are owned by VHCP Co-Invest II.
|
|
(2)
|
These shares are owned directly as follows: 838,956 shares are owned by VA7 and 69,497 shares are owned by VP7.
|
|
(3)
|
This percentage is calculated based upon 26,313,471 shares of the Issuer’s common stock outstanding as of November 5, 2015, as set forth in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.
|
Item 5.
|
Ownership of Five Percent or Less of a Class
|
Item 6.
|
Ownership of More than Five Percent on Behalf of Another Person
|
Item 7.
|
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.
|
Item 8.
|
Identification and Classification of Members of the Group
|
Item 9.
|
Notice of Dissolution of a Group
|
Item 10.
|
Certification
|
CUSIP No. 75901B107
|
Page 15 of 18
|
Venrock Healthcare Capital Partners, L.P.
|
||
By: VHCP Management, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
VHCP Co-Investment Holdings, LLC
|
||
By: VHCP Management, LLC
|
||
Its: Manager
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
VHCP Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
Venrock Healthcare Capital Partners II, L.P.
|
||
By: VHCP Management II, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
VHCP Co-Investment Holdings II, LLC
|
||
By: VHCP Management II, LLC
|
||
Its: Manager
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
VHCP Management II, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
CUSIP No. 75901B107
|
Page 16 of 18
|
Venrock Associates VII, L.P.
|
||
By: Venrock Management VII, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
Venrock Partners VII, L.P.
|
||
By: Venrock Partners Management VII, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
Venrock Management VII, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
A:
|
Joint Filing Agreement
|
CUSIP No. 75901B107
|
Page 17 of 18
|
Venrock Healthcare Capital Partners, L.P.
|
||
By: VHCP Management, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
VHCP Co-Investment Holdings, LLC
|
||
By: VHCP Management, LLC
|
||
Its: Manager
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
VHCP Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
Venrock Healthcare Capital Partners II, L.P.
|
||
By: VHCP Management II, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
VHCP Co-Investment Holdings II, LLC
|
||
By: VHCP Management II, LLC
|
||
Its: Manager
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
VHCP Management II, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
CUSIP No. 75901B107
|
Page 18 of 18
|
Venrock Associates VII, L.P.
|
||
By: Venrock Management VII, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
Venrock Partners VII, L.P.
|
||
By: Venrock Partners Management VII, LLC
|
||
Its: General Partner
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||
Venrock Management VII, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp
|
||
Authorized Signatory
|
||