SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934
For the month of April, 2007
SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.
Form 20-F X Form 40-F
Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
Yes No X
If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______
SkyePharma PLC ("the Company") Notification of Major Interest in Shares In accordance with paragraph 5.1.2 of the Disclosure and Transparency Rules, the Company has received a notification dated 13 April 2007 from Aviva plc and its subsidiaries ("Aviva") stating that as at 11 April 2007, it held a notifiable interest of 83,999,653 shares in SkyePharma PLC, which represents 10.31% of the voting rights in the Company. 9.62% are held directly and 0.69% are held indirectly. Direct holdings: BNY Norwich Union Nominees Limited 19,270,661 shares Chase GA Group Nominees Limited 41,674,191 shares Chase Nominees Limited 1,381,373 shares CUIM Nominee Limited 15,859,401 shares Vidacos Nominees Limited 222,791 shares 78,408,417 shares (9.62%) Indirect holdings: Chase Nominees Limited 1,361,734 shares CUIM Nominee Limited 859,130 shares Vidacos Nominees Limited 3,370,372 shares 5,591,236 Shares (0.69%) Prior to the triggering transaction, Aviva held 43,183,326 Ordinary Shares and notifies the Company that the percentage thresholds that have been crossed are 6% to 10% (inclusive) at the combined interest level.
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
By: /s/ John Murphy
Name: John Murphy
Title: Company Secretary
Date: April 17, 2007