SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934
For the month of April, 2007
SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.
Form 20-F X Form 40-F
Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
Yes No X
If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______
2 April 2007 SkyePharma PLC ("the Company") Notification of Major Interest in Shares In accordance with the Disclosure and Transparency Rules 5.1.2, we have received a notification dated 30 March 2007 from Lehman Brothers International (Europe) ("Lehman") stating that as at 28 March 2007, it held a notifiable interest of 37,565,323 shares in SkyePharma PLC, which represents 4.61% of the voting rights in the Company. Previous to the triggering transaction, Lehman held 39,975,648 Ordinary Shares. The notification states that the threshold that has been crossed or reached is 4%. END
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
By: /s/ John Murphy
Name: John Murphy
Title: Company Secretary
Date: April 02, 2007