SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934
For the month of March, 2007
SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.
Form 20-F X Form 40-F
Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
Yes No X
If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______
For immediate release 12 March 2007 SkyePharma PLC (the "Company") HOLDING IN COMPANY On 9 March 2007, the Company received notification by Aviva plc of a disclosure of a notifiable interest, following the implementation of the Transparency Directive, of 43,183,326 ordinary shares of 10p each representing 5.73% of the issued share capital in the Company. The notifiable interest comprises 41,335,090 ordinary shares, representing 5.48% being a direct holding and 1,848,236 ordinary shares, representing 0.25%, being held indirectly.
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
By: /s/ John Murphy
Name: John Murphy
Title: Company Secretary
Date: March 12, 2007