FORM 6-K

SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 

FORM 6-K

 

REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934

 

For the month of October, 2005

 

SkyePharma PLC


(Translation of registrant's name into English)

 

SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England


(Address of principal executive office)

 

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.

Form 20-F X      Form 40-F

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes         No X

If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______


 



For immediate release                                                                              24 October 2005
                                                       
                                                       
                                                       
                                        SkyePharma PLC ("the Company")
                                   Notification of Major Interest in Shares

In  accordance  with the  Companies  Act 1985 (as  amended)  the Company was  informed on 21 October  2005 that
Morgan  Stanley  Securities  Limited  ("MSSL")  had  a  notifiable  interest  of  23,831,840  Ordinary  Shares,
representing  3.79% of the issued  share  capital of the  Company.  The  majority of this  holding is for stock
borrowing and lending activity. MSSL is a member of the Morgan Stanley group of companies.

                                                   - ends -


SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

                                                                  SkyePharma PLC

                                                                      By: /s/ Douglas Parkhill

                                                                       Name: Douglas Parkhill
                                                                          Title: Company Secretary

Date:   October 24, 2005