FORM 6-K

SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 

FORM 6-K

 

REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934

 

For the month of October, 2005

 

SkyePharma PLC


(Translation of registrant's name into English)

 

SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England


(Address of principal executive office)

 

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.

Form 20-F X      Form 40-F

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes         No X

If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______


 


For immediate release                                                                         5 October 2005


                                                      SkyePharma PLC ("the Company")
                                                Notification of Interests of Directors


The Company was informed on 5 October 2005 by Michael  Ashton,  Chief  Executive  Officer of SkyePharma  PLC, that on 4 October 2005 he
purchased  59,000  Ordinary  Shares in the Company at a price of 42.5 pence per share.  The shares are  registered in the name of The M
Ashton  Pension  Scheme.  As a result of the  transaction  Mr Ashton now has a beneficial  interest in 570,369  Ordinary  Shares in the
Company.


                                                               - ends -


END


 

SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

                                                                  SkyePharma PLC

                                                                      By: /s/ Douglas Parkhill

                                                                       Name: Douglas Parkhill
                                                                          Title: Company Secretary

Date:   October 5, 2005