SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934
For the month of February, 2005
SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.
Form 20-F X Form 40-F
Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
Yes No X
If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______
For Immediate Release 16 February 2005
SkyePharma PLC ("the Company")
Notification of Major Interest in Shares
In accordance with the Companies Act 1985 (as amended) the Company was informed on 15 February 2005 that on 11 February 2005 Morgan Stanley Securities Limited ("MSSL") had a notifiable interest of 19,686,303 Ordinary Shares, representing 3.2% of the issued share capital of the Company. The majority of this holding is for stock borrowing and lending activity. MSSL is a member of the Morgan Stanley group of companies.END
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
By: /s/ Douglas Parkhill
Name: Douglas Parkhill
Title: Company Secretary
Date: February 16, 2005